Histone H2AX and the small RNA pathway modulate both non-homologous end-joining and homologous recombination in plants.
Authors: Qi Yiping, Zhang Yong, Baller Joshua A, Voytas Daniel F
Journal: Mutation research (Mutat Res), Vol.783(), 2016‑Jan
DOI:
10.1016/j.mrfmmm.2015.12.002
Abstract
Using a zinc finger nuclease (ZFN) that creates a site-specific DNA double-strand break (DSB) at the endogenous ADH1 locus, we provide genetic evidence that histone H2AX and DSB-induced small RNAs modulate DNA repair by both non-homologous end-joining (NHEJ) and homologous recombination (HR) in the model plant Arabidopsis thaliana.
Publication Types
Journal Article
Research Support, Non-U.S. Gov't
Keywords
Arabidopsis thaliana
DNA double-strand break (DSB) repair
H2AX
Small RNA
Zinc finger nuclease (ZFN)
Related Articles